Solution-Mediated Modulation of <i>Pseudomonas aeruginosa</i> Biofilm Formation by a Cationic Synthetic Polymer
Bacterial biofilms and their associated infections are a continuing problem in the healthcare community. Previous approaches utilizing anti-biofilm coatings suffer from short lifetimes, and their applications are limited to surfaces. In this research, we explored a new approach to biofilm prevention...
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| Main Authors: | , , |
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| Format: | Book |
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MDPI AG,
2019-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Bacterial biofilms and their associated infections are a continuing problem in the healthcare community. Previous approaches utilizing anti-biofilm coatings suffer from short lifetimes, and their applications are limited to surfaces. In this research, we explored a new approach to biofilm prevention based on the hypothesis that changing planktonic bacteria behavior to result in sub-optimal biofilm formation. The behavior of planktonic <i>Pseudomonas aeruginosa</i> exposed to a cationic polymer was characterized for changes in growth behavior and aggregation behavior, and linked to resulting <i>P. aeruginosa</i> biofilm formation, biomass, viability, and metabolic activity. The incubation of <i>P. aeruginosa</i> planktonic bacteria with a cationic polymer resulted in the aggregation of planktonic bacteria, and a reduction in biofilm development. We propose that cationic polymers may sequester planktonic bacteria away from surfaces, thereby preventing their attachment and suppressing biofilm formation. |
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| Item Description: | 2079-6382 10.3390/antibiotics8020061 |