CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8+Tim3+ exhausted T cells in non-small cell lung cancer

• Main Authors: Jian Wang (Author), Run-Ze Li (Author), Wen-Jun Wang (Author), Hu-Dan Pan (Author), Chun Xie (Author), Lee-Fong Yau (Author), Xing-Xia Wang (Author), Wei-Li Long (Author), Rui-Hong Chen (Author), Tu-Liang Liang (Author), Lin-Rui Ma (Author), Jia-Xin Li (Author), Ju-Min Huang (Author), Qi-Biao Wu (Author), Liang Liu (Author), Jian-Xing He (Author), Elaine Lai-Han Leung (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-small cell lung cancer (NSCLC) is one of the main malignant tumors with high mortality and short survival time. Immunotherapy has become the standard treatment for advanced NSCLC, but it has the problems of drug resistance and low response rate. Therefore, obtaining effective biomarkers to predi...