Synergistic cytotoxicity from combination of imatinib and platinum-based anticancer drugs specifically in Bcr-Abl positive leukemia cells

• Main Authors: Yuming Wei (Author), Kenneth K.W. To (Author), Steve C.F. Au-Yeung (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2015-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Imatinib, a multitargeted tyrosine kinase inhibitor, exhibits potent anticancer activity against leukemia harboring the Bcr-Abl oncogene and some solid tumors overexpressing c-kit and PDGFR. However, its clinical efficacy is severely compromised by the emergence of resistance primarily due to acquir...