Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo

• المؤلفون الرئيسيون: Lisa Nadal (مؤلف), Riccardo Corbellari (مؤلف), Alessandra Villa (مؤلف), Tobias Weiss (مؤلف), Michael Weller (مؤلف), Dario Neri (مؤلف), Roberto De Luca (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Antibody-based delivery of bioactive molecules represents a promising strategy for the improvement of cancer immunotherapy. Here, we describe the generation and characterization of R6N, a novel fully human antibody specific to the alternatively spliced domain D of Tenascin C, which is highly express...