Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo

• Hlavní autoři: Lisa Nadal (Autor), Riccardo Corbellari (Autor), Alessandra Villa (Autor), Tobias Weiss (Autor), Michael Weller (Autor), Dario Neri (Autor), Roberto De Luca (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Antibody-based delivery of bioactive molecules represents a promising strategy for the improvement of cancer immunotherapy. Here, we describe the generation and characterization of R6N, a novel fully human antibody specific to the alternatively spliced domain D of Tenascin C, which is highly express...