Fatal parvoviral myocarditis: A case report and review of literature

• Main Authors: Zhao Richard (Author), O'Malley Michael T (Author), Dalal Jay S (Author), Gonzalez-Cuyar Luis F (Author), Tavora Fabio (Author), Peng Hong Q (Author), Burke Allen P (Author)
• Format: Book
• Published: BMC, 2008-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>Histologically documented cases of parvoviral myocarditis are exceedingly rare.</p> <p>Case presentation</p> <p>Here, we report a 41-year old African American immunocompetent patient who died of parvoviral myocarditis after a 10 day illness characterized by fever, headaches, generalized arthralgias, and a maculopapular rash.</p> <p>Autopsy revealed an infiltrate myocarditis composed primarily of T-lymphocytes and macrophages associated with extensive myocardial fibrosis. The diagnosis of parvovirus was determined by polymerase chain reaction (PCR) on both pre-mortem serum and post-mortem myocardial tissue</p> <p>Methods</p> <p>DNA was extracted from tissue and serum and primers were used to amplify DNAsequences of parvovirus B19 using nested polymerase chain reaction (PCR).</p> <p>Conclusion</p> <p>The diagnosis of parvovirus should be considered in cases of fatal myocarditis, and diagnosis can be confirmed at autopsy by molecular techniques.</p>

Item Description

10.1186/1746-1596-3-21
1746-1596