The Chemical Components of <em>Sesbania grandiflora</em> Root and Their Antituberculosis Activity
Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of <em>Sesbania grandiflora</em>. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV...
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| Main Authors: | , , , , , |
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| Format: | Book |
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MDPI AG,
2012-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of <em>Sesbania grandiflora</em>. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, <sup>1</sup>H- and <sup>13</sup>C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1-4 exhibited antituberculosis activity against <em>Mycobacterium tuberculosis</em> H37Rv, with MIC values of 50 µg/mL for compounds 1-3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity. |
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| Item Description: | 10.3390/ph5080882 1424-8247 |