Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.

• Main Authors: Gabriele Pohlig (Author), Sonja C Bernhard (Author), Johannes Blum (Author), Christian Burri (Author), Alain Mpanya (Author), Jean-Pierre Fina Lubaki (Author), Alfred Mpoo Mpoto (Author), Blaise Fungula Munungu (Author), Patrick Mangoni N'tombe (Author), Gratias Kambau Manesa Deo (Author), Pierre Nsele Mutantu (Author), Florent Mbo Kuikumbi (Author), Alain Fukinsia Mintwo (Author), Augustin Kayeye Munungi (Author), Amadeu Dala (Author), Stephen Macharia (Author), Constantin Miaka Mia Bilenge (Author), Victor Kande Betu Ku Mesu (Author), Jose Ramon Franco (Author), Ndinga Dieyi Dituvanga (Author), Richard R Tidwell (Author), Carol A Olson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerated in healthy patients (for up to 21 days) and sta...