Clindamycin-Loaded Polyhydroxyalkanoate Nanoparticles for the Treatment of Methicillin-Resistant <i>Staphylococcus aureus-</i>Infected Wounds

• Main Authors: Muneeb Ullah (Author), Juho Lee (Author), Nurhasni Hasan (Author), Md. Lukman Hakim (Author), Dongmin Kwak (Author), Hyunwoo Kim (Author), Eunhye Lee (Author), Jeesoo Ahn (Author), Bora Mun (Author), Eun Hee Lee (Author), Yunjin Jung (Author), Jin-Wook Yoo (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<b>Background/Objectives:</b> Owing to the growing resistance of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) to conventional antibiotics, the development of innovative therapeutic strategies for the treatment of MRSA-infected cutaneous wounds poses a significant challenge. <b>Methods:</b> Here, by using polyhydroxyalkanoates (PHA), emerging biodegradable and biocompatible polymers naturally produced by various microorganisms, we developed clindamycin-loaded PHA nanoparticles (Cly-PHA NPs) as a novel approach for the treatment of MRSA-infected cutaneous wounds. <b>Results:</b> Cly-PHA NPs were characterized in terms of mean particle size (216.2 ± 38.9 nm), polydispersity index (0.093 ± 0.03), zeta potential (11.3 ± 0.5 mV), and drug loading (6.76 ± 0.19%). Owing to the sustained release of clindamycin over 2 days provided by the PHA, Cly-PHA NPs exhibited potent antibacterial effects against MRSA. Furthermore, Cly-PHA NPs significantly facilitated wound healing in a mouse model of MRSA-infected full-thickness wounds by effectively eradicating MRSA from the wound bed. <b>Conclusions:</b> Therefore, our results suggest that Cly-PHA NPs offer a promising approach for combating MRSA infections and accelerating cutaneous wound healing.

Item Description

10.3390/pharmaceutics16101315
1999-4923