Pharyngeal Pumping and Tissue-Specific Transgenic P-Glycoprotein Expression Influence Macrocyclic Lactone Susceptibility in <i>Caenorhabditis elegans</i>

• Main Authors: Alexander P. Gerhard (Author), Jürgen Krücken (Author), Cedric Neveu (Author), Claude L. Charvet (Author), Abdallah Harmache (Author), Georg von Samson-Himmelstjerna (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrocyclic lactones (MLs) are widely used drugs to treat and prevent parasitic nematode infections. In many nematode species including a major pathogen of foals, <i>Parascaris univalens</i>, resistance against MLs is widespread, but the underlying resistance mechanisms and ML penetratio...