A Fast and Simple Method for the Determination of TBA in <sup>18</sup>F-Labeled Radiopharmaceuticals
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various <sup>18</sup>F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the <sup>18<...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
MDPI AG,
2020-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various <sup>18</sup>F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the <sup>18</sup>F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up. |
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| Item Description: | 1424-8247 10.3390/ph13020027 |