A Fast and Simple Method for the Determination of TBA in <sup>18</sup>F-Labeled Radiopharmaceuticals
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various <sup>18</sup>F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the <sup>18<...
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| Format: | Book |
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MDPI AG,
2020-02-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_54e15c1e9ee242b39ee17f0d9bac2191 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Nils Erik Halvorsen |e author |
| 700 | 1 | 0 | |a Ole Heine Kvernenes |e author |
| 245 | 0 | 0 | |a A Fast and Simple Method for the Determination of TBA in <sup>18</sup>F-Labeled Radiopharmaceuticals |
| 260 | |b MDPI AG, |c 2020-02-01T00:00:00Z. | ||
| 500 | |a 1424-8247 | ||
| 500 | |a 10.3390/ph13020027 | ||
| 520 | |a A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various <sup>18</sup>F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the <sup>18</sup>F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up. | ||
| 546 | |a EN | ||
| 690 | |a tetrabutylammonium | ||
| 690 | |a tba | ||
| 690 | |a pet | ||
| 690 | |a quality control | ||
| 690 | |a spot test | ||
| 690 | |a radiopharmaceuticals | ||
| 690 | |a psma | ||
| 690 | |a fdopa | ||
| 690 | |a fdg | ||
| 690 | |a iodoplatinate | ||
| 690 | |a Medicine | ||
| 690 | |a R | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceuticals, Vol 13, Iss 2, p 27 (2020) | |
| 787 | 0 | |n https://www.mdpi.com/1424-8247/13/2/27 | |
| 787 | 0 | |n https://doaj.org/toc/1424-8247 | |
| 856 | 4 | 1 | |u https://doaj.org/article/54e15c1e9ee242b39ee17f0d9bac2191 |z Connect to this object online. |