Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

• Main Authors: Zheng-Wei Zhang (Author), Chun-Sheng Gao (Author), Heng Zhang (Author), Jian Yang (Author), Ya-Ping Wang (Author), Li-Bin Pan (Author), Hang Yu (Author), Chi-Yu He (Author), Hai-Bin Luo (Author), Zhen-Xiong Zhao (Author), Xin-Bo Zhou (Author), Yu-Li Wang (Author), Jie Fu (Author), Pei Han (Author), Yu-Hui Dong (Author), Gang Wang (Author), Song Li (Author), Yan Wang (Author), Jian-Dong Jiang (Author), Wu Zhong (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan (5-HTP) → ser...