Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator
Abstract Physiologically‐based pharmacokinetic (PBPK) modeling is being increasingly used in drug development to avoid unnecessary clinical drug-drug interaction (DDI) studies and inform drug labels. Thus, regulatory agencies are recommending, or indeed requesting, more rigorous demonstration of the...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2022-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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