NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

• Main Authors: Helton C Santiago (Author), Claudia Z Gonzalez Lombana (Author), Juan P Macedo (Author), Lara Utsch (Author), Wagner L Tafuri (Author), Maria José Campagnole-Santos (Author), Rosana O Alves (Author), José C F Alves-Filho (Author), Alvaro J Romanha (Author), Fernando Queiroz Cunha (Author), Mauro M Teixeira (Author), Rafael Radi (Author), Leda Q Vieira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(•)NO is considered to be a key macrophage-derived cytotoxic effector during Trypanosoma cruzi infection. On the other hand, the microbicidal properties of reactive oxygen species (ROS) are well recognized, but little importance has been attributed to them during in vivo infection with T. cruzi. In...