Effect of alkan-1-ols on the structure of dopc model membrane
The effect of general anaesthetics alkan-1-ols (CnOH, where n = 10, 12, 14, 16 and 18 is the number of carbon atoms in the molecule) on the structure of dioleoylphosphatidylcholine (DOPC) model membrane was studied by small-angle neutron scattering (SANS) and small-angle neutron diffraction (SAND)....
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| Format: | Book |
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Sciendo,
2017-11-01T00:00:00Z.
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| 001 | doaj_55e663b4187c4b2c810e69ce70331eb4 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kondela T. |e author |
| 700 | 1 | 0 | |a Gallová J. |e author |
| 700 | 1 | 0 | |a Hauß T. |e author |
| 700 | 1 | 0 | |a Ivankov O. |e author |
| 700 | 1 | 0 | |a Kučerka N. |e author |
| 700 | 1 | 0 | |a Balgavý P. |e author |
| 245 | 0 | 0 | |a Effect of alkan-1-ols on the structure of dopc model membrane |
| 260 | |b Sciendo, |c 2017-11-01T00:00:00Z. | ||
| 500 | |a 2453-6725 | ||
| 500 | |a 10.1515/afpuc-2017-0010 | ||
| 520 | |a The effect of general anaesthetics alkan-1-ols (CnOH, where n = 10, 12, 14, 16 and 18 is the number of carbon atoms in the molecule) on the structure of dioleoylphosphatidylcholine (DOPC) model membrane was studied by small-angle neutron scattering (SANS) and small-angle neutron diffraction (SAND). Fluid bilayers were prepared at CnOH:DOPC = 0.3 molar ratio. The results of both the experiments show that bilayer thickness - a thickness parameter dg in the case of SANS and lamellar repeat distance D in the case of SAND - increases with increasing n. A coexistence of two lamellar phases with different D was detected by measuring the C18OH+DOPC oriented sample. | ||
| 546 | |a EN | ||
| 690 | |a model membrane - general anaesthetics - alkan-1-ols - small-angle neutron scattering - small-angle neutron diffraction - structure | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n European Pharmaceutical Journal, Vol 64, Iss 2, Pp 4-8 (2017) | |
| 787 | 0 | |n https://doi.org/10.1515/afpuc-2017-0010 | |
| 787 | 0 | |n https://doaj.org/toc/2453-6725 | |
| 856 | 4 | 1 | |u https://doaj.org/article/55e663b4187c4b2c810e69ce70331eb4 |z Connect to this object online. |