Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system

• Päätekijät: Michiel van der Vaart (Tekijä), Joost J. van Soest (Tekijä), Herman P. Spaink (Tekijä), Annemarie H. Meijer (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2013-05-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

SUMMARY Toll-like receptors (TLRs) are an important class of pattern recognition receptors (PRRs) that recognize microbial and danger signals. Their downstream signaling upon ligand binding is vital for initiation of the innate immune response. In human and mammalian models, myeloid differentiation...