Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission

• Hlavní autoři: Nanshan Song (Autor), Hong Zhu (Autor), Rong Xu (Autor), Jiaqi Liu (Autor), Yinquan Fang (Autor), Jing Zhang (Autor), Jianhua Ding (Autor), Gang Hu (Autor), Ming Lu (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson's disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and amplify neuronal loss. Hence, intensive control...