Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission

• Hauptverfasser: Nanshan Song (Verfasst von), Hong Zhu (Verfasst von), Rong Xu (Verfasst von), Jiaqi Liu (Verfasst von), Yinquan Fang (Verfasst von), Jing Zhang (Verfasst von), Jianhua Ding (Verfasst von), Gang Hu (Verfasst von), Ming Lu (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson's disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and amplify neuronal loss. Hence, intensive control...