Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission

• Ngā kaituhi matua: Nanshan Song (Author), Hong Zhu (Author), Rong Xu (Author), Jiaqi Liu (Author), Yinquan Fang (Author), Jing Zhang (Author), Jianhua Ding (Author), Gang Hu (Author), Ming Lu (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson's disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and amplify neuronal loss. Hence, intensive control...