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N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an IC50 of 2.6 µM as a chemical starting point for...

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Bibliographic Details
Main Authors: Naresh Sunduru (Author), Mona Svensson (Author), Mariateresa Cipriano (Author), Sania Marwaha (Author), C. David Andersson (Author), Richard Svensson (Author), Christopher J. Fowler (Author), Mikael Elofsson (Author)
Format: Book
Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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Summary:Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an IC50 of 2.6 µM as a chemical starting point for the development of potent FAAH inhibitors. Preliminary hit-to-lead optimisation resulted in 2-(4-phenylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4i, with an IC50 of 0.35 µM.
Item Description:1475-6366
1475-6374
10.1080/14756366.2016.1265520

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