Lipid-Lowering and Antioxidant Functions of Bottle Gourd () Extract in Human Dyslipidemia

• Main Authors: Charu Katare PhD (Author), Sonali Saxena PhD (Author), Supriya Agrawal MSc (Author), Anish Zacharia Joseph PhD (Author), Senthil Kumar Subramani MSc (Author), Dhananjay Yadav PhD (Author), Nita Singh MSc (Author), Prakash Singh Bisen PhD, DSc (Author), G. B. K. S. Prasad PhD (Author)
• Format: Book
• Published: SAGE Publishing, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions ( P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index ( P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction ( P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD ( P < .05) and GSH levels ( P < .01) with marked improvement in catalase ( P < .01) and TBARS levels ( P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease.

Item Description

2156-5872
2156-5899
10.1177/2156587214524229