The role of asthma's basic therapy in the development of endothelial dysfunction in children
<p><strong>Purpose</strong> - estimation of basic anti-inflammatory therapy with inhaled glucocorticoids in the development of endothelial dysfunction in children with asthma. <strong>Materials and methods</strong>. Comprehensively examined 224 children with asthma, age...
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| Main Authors: | , |
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| Format: | Book |
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Nicolaus Copernicus University in Toruń, Poland - University Sports Center,
2015-02-01T00:00:00Z.
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| Summary: | <p><strong>Purpose</strong> - estimation of basic anti-inflammatory therapy with inhaled glucocorticoids in the development of endothelial dysfunction in children with asthma. <strong>Materials and methods</strong>. Comprehensively examined 224 children with asthma, aged 6 - 17 years, with determination of homocysteine and vascular endothelial growth factor. 40 healthy children were examined as a control group. <strong>Results.</strong> Established that the likelihood of adverse effects when using the highest GCI monotherapy (OR 8,889; 95% CI 4,803 - 16,449) and combination therapy with mast cell membranes stabilizeres (OR 1,111; 95% CI1,051 - 2,734). Determined that the risk factors increase homocysteine than 17.36 (11.3 - 24.5) mmol / l and VEGF above 431.66 (238.04 - 658.09) pg / ml in serum of children with asthma were using of doses aerosol inhalators without conveying device and without increasing of IGC dose.</p> |
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| Item Description: | 2450-6605 2450-6605 10.12775/PPS.2015.01.02.004 |