Ciprofloxacin and pegylated G-CSF combined therapy mitigates brain hemorrhage and mortality induced by ionizing irradiation

• Main Authors: Juliann G. Kiang (Author), Georgetta Cannon (Author), Matthew G. Olson (Author), Min Zhai (Author), Akeylah K. Woods (Author), Feng Xu (Author), Bin Lin (Author), Xianghong Li (Author), Lisa Hull (Author), Suping Jiang (Author), Mang Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionBrain hemorrhage was found between 13 and 16 days after acute whole-body 9.5 Gy 60Co-γ irradiation (IR). This study tested countermeasures mitigating brain hemorrhage and increasing survival from IR. Previously, we found that pegylated G-CSF therapy (PEG) (i.e., Neulasta®, an FDA-approve...