Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake

• Main Authors: Motahareh Solina Safari (Author), Priska Woerl (Author), Carolin Garmsiri (Author), Dido Weber (Author), Marcel Kwiatkowski (Author), Madlen Hotze (Author), Louisa Kuenkel (Author), Luisa Lang (Author), Matthias Erlacher (Author), Ellen Gelpi (Author), Johannes A. Hainfellner (Author), Gottfried Baier (Author), Gabriele Baier-Bitterlich (Author), Stephanie zur Nedden (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucose-1,6-bisphosphate (G-1,6-BP), a byproduct of glycolysis that is synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in neurons. G-1,6-BP is sensitive to the glycolytic flux, due to its dependence on 1,3-bisphosphoglycerate as phosphate donor, and the energ...