Fraxetin attenuates disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress

• Main Authors: Zainab Ahmed (Author), Ahmed Tokhi (Author), Mehreen Arif (Author), Naeem Ur Rehman (Author), Vahid Sheibani (Author), Khalid Rauf (Author), Robert D. E. Sewell (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Chronic unpredictable stress (CUS) induces long-term neuronal and synaptic plasticity with a neurohormonal disbalance leading to the development of co-existing anxiety, depression, and cognitive decline. The side effects and delayed onset of current clinically used antidepressants has promp...