Activating and inactivating mutations of the human, rat, equine and eel luteinizing hormone/ chorionic gonadotropin receptors (LH/CGRs)
Mutations in the luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs), representatives of the G protein-coupled receptor family, have been rapidly identified over the last 20 years. This review aims to compare and analyze the data reported the activating and inactivating mutations of the L...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
The Korean Society of Animal Reproduction and Biotechnology,
2021-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Mutations in the luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs), representatives of the G protein-coupled receptor family, have been rapidly identified over the last 20 years. This review aims to compare and analyze the data reported the activating and inactivating mutations of the LH/CGRs between human, rat, equine and fish, specifically (Japanese eel Anguilla japonica). Insights obtained through detailed study of these naturally-occurring mutations provide a further update of structure-function relationship of these receptors. Specifically, we present a variety of data on eel LH/CGR. These results provide important information about LH/CGR function in fish and the regulation of mutations of the highly conserved amino acids in glycoprotein hormone receptors. |
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| Item Description: | 10.12750/JARB.36.4.169 2671-4639 2671-4663 |