Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics

• Asıl Yazarlar: Nels Thorsteinson (Yazar), John R. Gunn (Yazar), Kenneth Kelly (Yazar), Will Long (Yazar), Paul Labute (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The effect of hydrophobicity on antibody aggregation is well understood, and it has been shown that charge calculations can be useful for high-concentration viscosity and pharmacokinetic (PK) clearance predictions. In this work, structure-based charge descriptors are evaluated for their predictive p...