Can mouth washes containing chlorhexidine 0.12% be used as synonym of a water solution of chlorhexidine 0.12%?

• Main Authors: Ivana Barbosa Suffredini (Author), Cintia Helena Coury Saraceni (Author), Ingrit Elida Collantes Díaz (Author)
• Format: Book
• Published: Universidade de São Paulo, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Chlorhexidine digluconate (CHX) is a gold standard drug in dentistry and is widely used as a reference in both <italic>in vitro</italic> and <italic>in vivo</italic>experiments. Due to ease of access, mouth washes containing CHX 0.12% are used as a substitute for aqueous CHX 0.12% solution in laboratory experiments. Additionally, it is well known that for product flavor purposes, volatile compounds are added to mouth washes formulations. Volatiles added to CHX 0.12% may improve wash's antibacterial ability. Volatiles add potency to the mouth wash formulation. Compared with an aqueous CHX 0.12% solution, it is proposed that CHX solutions and Periogard^® would have antimicrobial activity. Antimicrobial activity was assessed in the present study via disk diffusion assays against <italic>Streptococcus mutans</italic>, <italic>Streptococcus sanguinis</italic>and <italic>Escherichia coli</italic>. Periogard^® showed a significantly higher antibacterial activity in relation to CHX 0.12% (p<0.05) and a similar activity in relation to CHX 1% (p>0.05). Periogard^(r) volatiles were analyzed by gas-chromatography/mass spectrometry (GCMS) and the presence of antibacterial menthol, menthone, isomenthol, menthyl acetate, trans-anethol and eugenol was verified. Finally, the use of Periogard^® as a synonym of CHX 0.12% must be avoided, because its antibacterial activity is closely related to CHX 1%.</p>

Item Description

2175-9790
10.1590/S1984-82502015000200014