Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro
Background: Serum neopterin concentrations rise during activation of the cellular immune system. It is suggested that neopterin interacts with cellular redox mechanisms. This induces oxidative stress, which inhibits intracellular Ca2+ transients in various cell types. In type II alveolar epithelial...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Hindawi Limited,
2002-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Background: Serum neopterin concentrations rise during activation of the cellular immune system. It is suggested that neopterin interacts with cellular redox mechanisms. This induces oxidative stress, which inhibits intracellular Ca2+ transients in various cell types. In type II alveolar epithelial cells, Ca2+ increase is considered involved in the exocytosis of surfactants. This exocytosis is disturbed during inflammation. |
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| Item Description: | 0962-9351 1466-1861 10.1080/09622935020138217 |