Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression

• Main Authors: Mifetika Lukitasari BSN, MSc (Author), Dwi Adi Nugroho MD, MSc (Author), Nashi Widodo PhD (Author)
• Format: Book
• Published: SAGE Publishing, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2515-690X; 10.1177/2515690X18789628
• Keywords: Other systems of medicine; RZ201-999; Homeopathy; RX1-681
• Source: Journal of Evidence-Based Integrative Medicine, Vol 23 (2018)

New paradigm in cancer pathogenesis revealed that microenvironmental conditions significantly contribute to cancer. Hence, Warburg stated that cancer is a metabolic disease. Chlorogenic acid (CGA) is a polyphenol that is found abundantly in coffee. This compound has proven ability in ameliorating some metabolic diseases through various pathways. This article will elaborate the potency of CGA as a chemosensitizer in suppressing tumor growth through a metabolic pathway. AMPK pathway is the main cell metabolic pathway that is activated by CGA in some studies. Moreover, CGA inhibited EGFR/PI3K/mTOR, HIF, VEGF pathways and MAPK/ERK pathway that may suppress tumor cell growth. Furthermore, CGA induced intracellular DNA damage and topoisomerase I- and II-DNA complexes formation that plays a key role in apoptosis. Conclusively, based on the ability of CGA in activate and inhibit some important pathways in cancer metabolism, it may act as a chemosensitizing agent leading to cancer growth suppression.