Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study

• Hauptverfasser: Meng Q (VerfasserIn), Yang G (VerfasserIn), Li R (VerfasserIn), Nie J (VerfasserIn), Zhou W (VerfasserIn), Yu H (VerfasserIn), Chen B (VerfasserIn), Jiang L (VerfasserIn), Shang J (VerfasserIn)
• Format: Buch
• Veröffentlicht: Dove Medical Press, 2017-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.
• Notes: 1177-8881
• Keywords: Spinal cord injury; Poly(ADP-ribose) polymerase-1; Polymorphism; Therapeutics. Pharmacology; RM1-950
• Source: Drug Design, Development and Therapy, Vol Volume 11, Pp 3491-3495 (2017)

Qing-Tao Meng,* Guang Yang,* Ren-Bo Li, Jing-Xin Nie, Wei Zhou, Hong-De Yu, Bo Chen, Li Jiang, Jing-Bo Shang Department of Spine Surgery, The Third People&rsquo;s Hospital of Dalian, Dalian, People&rsquo;s Republic of China *These authors contributed equally to this work Objective: We aimed to evaluate whether the polymorphism of poly(ADP-ribose) polymerase-1 (PARP-1) is involved as potential risk factor in the development of spinal cord injury (SCI) among Chinese individuals.Patients and methods: Patients with a confirmed diagnosis of SCI (other than traumatic injury) and healthy individuals with no clinical symptoms of SCI were enrolled at Spinal Cord Injury Care Center, The Third People&rsquo;s Hospital of Dalian, China. Genetic polymorphisms were studied in plasma samples by polymerase chain reaction-restriction fragment length polymorphism assay.Results: A total of 130 Chinese patients with SCI and 130 healthy Chinese individuals were included. We found that patients with the GG genotype (odds ratio [OR]: 4.09, 95% confidence interval [CI] 2.42&ndash;6.90, P<0.001) and carriers of the G allele (OR 3.96, 95% CI 2.33&ndash;6.74, P<0.0001) were at high risk of developing SCI. A del/ins polymorphism of the NF-&kappa;B1 gene (OR 3.32, 95% CI 1.96&ndash;5.61, P<0.001) was also found to be associated with SCI.Conclusion: Our study suggests that PARP-1 polymorphisms are involved in the development of SCI in Chinese individuals. Thus, PARP-1 polymorphisms can be considered as one of the potential risk factors for developing SCI. Keywords: spinal cord injury, poly(ADP-ribose) polymerase-1, polymorphism&nbsp;