Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

• المؤلفون الرئيسيون: Luca Piemontese (مؤلف), Daniel Tomás (مؤلف), Asha Hiremathad (مؤلف), Vito Capriati (مؤلف), Emanuel Candeias (مؤلف), Sandra M. Cardoso (مؤلف), Sílvia Chaves (مؤلف), M. Amélia Santos (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer's disease (AD) agents. The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bio...