Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

• Main Authors: Luca Piemontese (Author), Daniel Tomás (Author), Asha Hiremathad (Author), Vito Capriati (Author), Emanuel Candeias (Author), Sandra M. Cardoso (Author), Sílvia Chaves (Author), M. Amélia Santos (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer's disease (AD) agents. The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bio...