Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

• Principais autores: Luca Piemontese (Autor), Daniel Tomás (Autor), Asha Hiremathad (Autor), Vito Capriati (Autor), Emanuel Candeias (Autor), Sandra M. Cardoso (Autor), Sílvia Chaves (Autor), M. Amélia Santos (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer's disease (AD) agents. The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bio...