Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates

• Автори: Luca Piemontese (Автор), Daniel Tomás (Автор), Asha Hiremathad (Автор), Vito Capriati (Автор), Emanuel Candeias (Автор), Sandra M. Cardoso (Автор), Sílvia Chaves (Автор), M. Amélia Santos (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer's disease (AD) agents. The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bio...