Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

• Main Authors: Jinbo Hu (Author), Wen Liu (Author), Yi Zou (Author), Chenyang Jiao (Author), Jiazhen Zhu (Author), Qiang Xu (Author), Jianjun Zou (Author), Yang Sun (Author), Wenjie Guo (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth, differentiation, and survival. The activation of SHP2 has been shown to have a therapeutic effect in colitis and...