Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose

• Main Authors: Kiera Walker (Author), Nathaniel H. Boyd (Author), Joshua C. Anderson (Author), Christopher D. Willey (Author), Anita B. Hjelmeland (Author)
• Format: Book
• Published: BMC, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model physiologic levels, nor the diminished concentrations found in tumor niche...