High Heme and Low Heme Oxygenase-1 Are Associated with Mast Cell Activation/Degranulation in HIV-Induced Chronic Widespread Pain

• Ngā kaituhi matua: Tanima Chatterjee (Author), Itika Arora (Author), Lilly Underwood (Author), Anastasiia Gryshyna (Author), Terry L. Lewis (Author), Juan Xavier Masjoan Juncos (Author), Burel R. Goodin (Author), Sonya Heath (Author), Saurabh Aggarwal (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2023-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

An overwhelming number of people with HIV (PWH) experience chronic widespread pain (CWP) throughout their lifetimes. Previously, we demonstrated that PWH with CWP have increased hemolysis and attenuated heme oxygenase 1 (HO-1) levels. HO-1 degrades reactive, cell-free heme into antioxidants like bil...