Neurosurgical Techniques for Disruption of the Blood-Brain Barrier for Glioblastoma Treatment
The blood-brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood-brain barrier (BBB). We will review superselective intra-arterial mannito...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
MDPI AG,
2015-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The blood-brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood-brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood-brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal. |
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| Item Description: | 1999-4923 10.3390/pharmaceutics7030175 |