Neurosurgical Techniques for Disruption of the Blood-Brain Barrier for Glioblastoma Treatment
The blood-brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood-brain barrier (BBB). We will review superselective intra-arterial mannito...
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| Format: | Book |
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MDPI AG,
2015-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_5889efa521c64c78a20b4a2fb0c77ef0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Analiz Rodriguez |e author |
| 700 | 1 | 0 | |a Stephen B. Tatter |e author |
| 700 | 1 | 0 | |a Waldemar Debinski |e author |
| 245 | 0 | 0 | |a Neurosurgical Techniques for Disruption of the Blood-Brain Barrier for Glioblastoma Treatment |
| 260 | |b MDPI AG, |c 2015-08-01T00:00:00Z. | ||
| 500 | |a 1999-4923 | ||
| 500 | |a 10.3390/pharmaceutics7030175 | ||
| 520 | |a The blood-brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood-brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood-brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal. | ||
| 546 | |a EN | ||
| 690 | |a blood-brain barrier | ||
| 690 | |a intra-arterial drug delivery | ||
| 690 | |a focused ultrasound | ||
| 690 | |a laser interstitial thermotherapy | ||
| 690 | |a non-thermal irreversible electroporation | ||
| 690 | |a glioblastoma | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 7, Iss 3, Pp 175-187 (2015) | |
| 787 | 0 | |n http://www.mdpi.com/1999-4923/7/3/175 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/5889efa521c64c78a20b4a2fb0c77ef0 |z Connect to this object online. |