The estimation and translation uncertainties in applying NOAEL to clinical dose escalation
Abstract The systemic exposure at the no‐observed‐adverse‐effect‐level (NOAEL) estimated from animals is an important criterion commonly applied to guard the safety of participants in clinical trials of investigational drugs. However, the discrepancy in toxicity profile between species is widely rec...
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| Main Authors: | , , |
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| Format: | Book |
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Wiley,
2024-06-01T00:00:00Z.
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