Role of Ca2+ signaling in skeletal muscle hypertrophy and atrophy
Skeletal muscle maintains an adequate volume that is commensurate with its surrounding environment. Although intracellular signaling molecules and pathways underlying the regulation of protein synthesis/degradation and subsequent muscle hypertrophy/atrophy are well studied, upstream regulators are l...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
Japanese Society of Physical Fitness and Sports Medicine,
2015-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Skeletal muscle maintains an adequate volume that is commensurate with its surrounding environment. Although intracellular signaling molecules and pathways underlying the regulation of protein synthesis/degradation and subsequent muscle hypertrophy/atrophy are well studied, upstream regulators are largely unknown. In this review, we summarize the recent advances relating to the role of Ca2+ signaling as an upstream regulator of intracellular signaling pathways that regulate muscle plasticity, suggesting a new therapeutic target to control muscle mass. |
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| Item Description: | 2186-8131 2186-8123 10.7600/jpfsm.4.171 |