Glutamate transporter: an unexpected target for some antibiotics
<p>Abstract</p> <p>Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, Rothstein et al (2005) reports that t...
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SAGE Publishing,
2005-02-01T00:00:00Z.
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| Summary: | <p>Abstract</p> <p>Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, Rothstein et al (2005) reports that the most commonly used class of antibiotics (β-lactam antibiotics) such as ceftriaxone promoted the expression of GLT1 and demonstrated a functional role in both <it>in vitro </it>and <it>in vivo </it>models of glutamate neurotocixity. These findings indicate that positive promoters of GT expression may have a unique role in neuroprotection through regulating GT expression. This is also encouraging in search for new pharmacological tools for pain management.</p> |
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| Item Description: | 10.1186/1744-8069-1-5 1744-8069 |