Glutamate transporter: an unexpected target for some antibiotics
<p>Abstract</p> <p>Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, Rothstein et al (2005) reports that t...
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SAGE Publishing,
2005-02-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_58f5ea30b21b4ef0b5dafb84a8f8b101 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mao Jianren |e author |
| 245 | 0 | 0 | |a Glutamate transporter: an unexpected target for some antibiotics |
| 260 | |b SAGE Publishing, |c 2005-02-01T00:00:00Z. | ||
| 500 | |a 10.1186/1744-8069-1-5 | ||
| 500 | |a 1744-8069 | ||
| 520 | |a <p>Abstract</p> <p>Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, Rothstein et al (2005) reports that the most commonly used class of antibiotics (β-lactam antibiotics) such as ceftriaxone promoted the expression of GLT1 and demonstrated a functional role in both <it>in vitro </it>and <it>in vivo </it>models of glutamate neurotocixity. These findings indicate that positive promoters of GT expression may have a unique role in neuroprotection through regulating GT expression. This is also encouraging in search for new pharmacological tools for pain management.</p> | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Molecular Pain, Vol 1, Iss 1, p 5 (2005) | |
| 787 | 0 | |n http://www.molecularpain.com/content/1/1/5 | |
| 787 | 0 | |n https://doaj.org/toc/1744-8069 | |
| 856 | 4 | 1 | |u https://doaj.org/article/58f5ea30b21b4ef0b5dafb84a8f8b101 |z Connect to this object online. |