Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells

• Main Authors: Iraselia Garcia (Author), Wendy Innis-Whitehouse (Author), Alma Lopez (Author), Megan Keniry (Author), Robert Gilkerson (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To explore the impact of oxidative insults on mitochondrial dynamics. In mammalian cells, oxidative insults activate stress response pathways including inflammation, cytokine secretion, and apoptosis. Intriguingly, mitochondria are emerging as a sensitive network that may function as an e...