QSAR, ADMET In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Studies of Novel Bicyclo (Aryl Methyl) Benzamides as Potent GlyT1 Inhibitors for the Treatment of Schizophrenia

• Main Authors: Mohamed El fadili (Author), Mohammed Er-Rajy (Author), Mohammed Kara (Author), Amine Assouguem (Author), Assia Belhassan (Author), Amal Alotaibi (Author), Nidal Naceiri Mrabti (Author), Hafize Fidan (Author), Riaz Ullah (Author), Sezai Ercisli (Author), Sara Zarougui (Author), Menana Elhallaoui (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Forty-four bicyclo ((aryl) methyl) benzamides, acting as glycine transporter type 1 (GlyT1) inhibitors, are developed using molecular modeling techniques. QSAR models generated by multiple linear and non-linear regressions affirm that the biological inhibitory activity against the schizophrenia dise...