Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• मुख्य लेखकों: Rocío Gambaro (लेखक), Ignacio Rivero Berti (लेखक), María José Limeres (लेखक), Cristián Huck-Iriart (लेखक), Malin Svensson (लेखक), Silvia Fraude (लेखक), Leah Pretsch (लेखक), Shutian Si (लेखक), Ingo Lieberwirth (लेखक), Stephan Gehring (लेखक), Maximiliano Cacicedo (लेखक), Germán Abel Islan (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...