Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Asıl Yazarlar: Rocío Gambaro (Yazar), Ignacio Rivero Berti (Yazar), María José Limeres (Yazar), Cristián Huck-Iriart (Yazar), Malin Svensson (Yazar), Silvia Fraude (Yazar), Leah Pretsch (Yazar), Shutian Si (Yazar), Ingo Lieberwirth (Yazar), Stephan Gehring (Yazar), Maximiliano Cacicedo (Yazar), Germán Abel Islan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2024-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...