Comparing the effects of two different progesterone vaginal gels, Progeson™ and Crinone™, from pharmacokinetics study to clinical applications in patients undergone fresh embryo transfer and frozen-thawed embryo transfer via natural cycle endometrial preparation protocol
Objective: The pharmacokinetics performance and clinical pregnancy rate of two vaginal progesterone gel, Progeson™ and Crinone™, were compared in this study. Materials and methods: In the pharmacokinetics performance, Progeson showed similar long-term dissolution rate as Crinone. In the clinical stu...
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Elsevier,
2023-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_595e2097b83d4d8da2c29cb1a76afab6 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Cheng-Wei Yu |e author |
| 700 | 1 | 0 | |a Wei-Jiun Li |e author |
| 700 | 1 | 0 | |a Wen-Chi Hsieh |e author |
| 700 | 1 | 0 | |a Li-Shan Chen |e author |
| 700 | 1 | 0 | |a Yi-Ping Li |e author |
| 245 | 0 | 0 | |a Comparing the effects of two different progesterone vaginal gels, Progeson™ and Crinone™, from pharmacokinetics study to clinical applications in patients undergone fresh embryo transfer and frozen-thawed embryo transfer via natural cycle endometrial preparation protocol |
| 260 | |b Elsevier, |c 2023-03-01T00:00:00Z. | ||
| 500 | |a 1028-4559 | ||
| 500 | |a 10.1016/j.tjog.2022.12.002 | ||
| 520 | |a Objective: The pharmacokinetics performance and clinical pregnancy rate of two vaginal progesterone gel, Progeson™ and Crinone™, were compared in this study. Materials and methods: In the pharmacokinetics performance, Progeson showed similar long-term dissolution rate as Crinone. In the clinical study, 141 subjects undergone in vitro fertilization (IVF) treatments were included to compare serum progesterone level and clinical pregnancy rates. Results: Among the subjects, 78 subjects received fresh embryo transfer and 63 subjects received frozen embryo transfer via natural cycle endometrial preparation protocol. In each group, subjects were given either Crinone™ or Progeson™ for luteal phase support without combination with other progesterone products. The study showed that Crinone™ group led to higher estrogen level at mid-luteal phase in the fresh embryo transfer group, and Progeson™ group led to higher progesterone level at mid-luteal phase and pregnancy test day in the frozen-thawed embryo transfer group. Conclusion: Subjects received Crinone™ or Progeson™ had similar rate of pregnancy, live birth, and stillbirth in both fresh embryo transfer and frozen-thawed embryo transfer group. Thus, Progeson™ might be a suitable substitute for Crinone™ in assisted reproductive therapy. | ||
| 546 | |a EN | ||
| 690 | |a IVF | ||
| 690 | |a Infertility | ||
| 690 | |a Progesterone | ||
| 690 | |a Pharmacokinetics | ||
| 690 | |a Pregnancy | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Taiwanese Journal of Obstetrics & Gynecology, Vol 62, Iss 2, Pp 280-285 (2023) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1028455923000256 | |
| 787 | 0 | |n https://doaj.org/toc/1028-4559 | |
| 856 | 4 | 1 | |u https://doaj.org/article/595e2097b83d4d8da2c29cb1a76afab6 |z Connect to this object online. |